The A96 Aberdeen to Inverness road has been closed in both directions at Inverurie following a collision between a car and a large goods vehicle.
Emergency services were called just before 2pm following reports of a crash.
The fire service has sent two appliances to the scene and one person is trapped inside a vehicle.
Diversions are in place through Inverurie.
A fire service spokeswoman said: “We were called at 1.54pm following a crash between a car and a large good vehicle.
“One person is trapped inside a vehicle.”
A police spokesman added: “The road is closed in both directions.”
Update: A woman in her forties has been transported to Aberdeen Royal Infirmary with serious injuries following the crash.
An ambulance spokesman confirmed they were “not life-threatening.”