The A82 has been blocked by a car crash between Drumnadrochit and Invermoriston.
Two cars, containing three people, were involved in the collision at Alltsigh just after 10am near the Loch Ness Youth Hostel.
One lane of the Inverness to Fort William road is currently passable but a police spokesman said the road was likely to close for a period for the vehicles to be recovered.
All three people involved are said to be conscious and breathing.
However, the air ambulance helicopter has been called to the scene to remove one of the victims to hospital.