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Study shows ‘substantial reduction’ in hospital admissions four weeks after first Covid jab

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Vaccination has been linked to a substantial reduction in the risk of Covid admissions to Scotland’s hospitals, a new landmark study has said.

The vaccines could reduce a person’s risk of being admitted by as much as 94% four weeks after the first dose.

Experts examined Covid hospital admissions in Scotland among people who have had their first jab and compared them to those who had not yet received a vaccine.

Scientists from the Universities of Edinburgh, Strathclyde, Aberdeen, Glasgow and St Andrews and Public Health Scotland (PHS) looked at data on people who had received either either the Pfizer/BioNTech vaccine or the one developed by scientists at the University of Oxford with AstraZeneca.

Four weeks after receiving the initial dose, the Oxford jab appeared to reduce a person’s risk of hospital admission by 94%.

Nursing staff applaud as Paula McMahon receives the Pfizer/BioNTech Covid-19 vaccine jab at the NHS Louisa Jordan Hospital in Glasgow, on the first day of the largest immunisation programme in the UK’s history.

Those who received the Pfizer jab had a reduction in risk of 85% between 28 and 34 days after the first dose.

Data for the two jabs combined showed that among people over the age of 80 – who are at high risk of severe disease – the reduction in risk of hospital admission was 81% four weeks after the first dose.

Lead researcher, professor Aziz Sheikh, director of the University of Edinburgh’s Usher Institute, said: “These results are very encouraging and have given us great reasons to be optimistic for the future.

“We now have national evidence – across an entire country – that vaccination provides protection against Covid-19 hospitalisations.

“Rollout of the first vaccine dose now needs to be accelerated globally to help overcome this terrible disease.”

The study team said the findings are applicable to other countries using the Pfizer and Oxford/AstraZeneca vaccines.

Scientists from Aberdeen University were involved in the study.

The study is the first to describe a country-wide effect of the Pfizer and Oxford-AstraZeneca doses in the community on preventing severe illness resulting in hospital admissions.

The researchers examined data between between December 8 and February 15.

These results are very encouraging and have given us great reasons to be optimistic for the future.

Professor Aziz Sheikh

During this period, 1.14 million vaccines were administered in Scotland – 21% of the Scottish population.

The Pfizer vaccine has been received by some 650,000 people, while 490,000 have had the Oxford-AstraZeneca vaccine.

‘Reason to be more optimistic’

Researchers looked at GP records on vaccination, hospital admissions, death registrations and laboratory test results – and compared the outcomes of those who had received their first jab with those who had not.

Dr Jim McMenamin, national Covid-19 incident director at PHS, said: “Across the Scottish population the results show a substantial effect on reducing the risk of admission to hospital from a single dose of vaccine.

“For anyone offered the vaccine I encourage them to get vaccinated.”

Researcher Dr Josie Murray, from PHS, added: “These data show real promise that the vaccines we have given out can protect us from the severe effects of Covid-19.

“We must not be complacent though.

Coronavirus in Scotland – tracking the recovery

“We all still need to ensure we stop transmission of the virus, and the best way we can all do this is to follow public health guidance – wash your hands often, keep two metres from others, and if you develop symptoms, isolate and take a test.

“We also all need to protect ourselves, our families and friends by taking the second dose of vaccine when it is offered.”

Chris Robertson, professor of public health epidemiology at the University of Strathclyde, said: “These early national results give a reason to be more optimistic about the control of the epidemic.”