Southampton midfielder Sofiane Boufal is a major doubt for the Premier League match against bottom club Watford after stubbing his big toe on the kitchen table at home.
Stuart Armstrong picked up a hamstring problem during the closing stages against Arsenal and the midfielder is expected to be out for at least a couple of weeks.
Defender Jannik Vestergaard has been able to resume training following illness so should be involved again.
Watford will be without defender Craig Dawson, who needed stitches in a head wound suffered during the 3-0 home defeat by Burnley.
Christian Kabasele has a hamstring problem, while Dutch defender Daryl Janmaat (knee) is also not available.
Roberto Pereyra is stepping up his recovery from a thigh strain but is unlikely to be risked. Tom Cleverley (heel), Danny Welbeck (hamstring), Sebastian Prodl (knee) and Domingos Quina (groin) all continue their own rehabilitation.
Provisional Southampton squad: McCarthy, Soares, Stephens, Bertrand, Bednarek, Ward-Prowse, Romeu, Redmond, Hojbjerg, Ings, Obafemi, Gunn, Yoshida, Valery, Vestergaard, Adams, Long, Djenepo, Boufal
Watford provisional squad: Foster, Masina, Mariappa, Cathcart, Kiko, Holebas, Doucoure, Hughes, Capoue, Deulofeu, Gray, Gomes, Foulquier, Mukena, Chalobah, Sarr, Dele-Bashiru, Deeney