Ousseynou Cisse could be handed his first start for Leyton Orient as they look to end a five-game winless run against Northampton.
The 28-year-old midfielder joined the O’s on loan from Gillingham on Friday and made his debut as a substitute during Saturday’s 1-0 defeat to Port Vale.
Jamie Turley looks unlikely to feature after missing out at the weekend due to an injury sustained during the draw with Grimsby.
Jobi McAnuff (groin) and Dean Brill (hamstring) remain sidelined with long-term injuries.
Northampton boss Keith Curle will not rush the return of midfielder Alan McCormack.
The Irishman returned to training at the beginning of the year after struggling with an unspecified injury but he has yet to make a competitive comeback.
Harry Smith is still sidelined after sustaining an ankle injury during the Boxing Day clash with Crawley.
Shaun McWilliams also suffered a knee injury during the same fixture and faces a lengthy spell on the sidelines.