Chalmers Hospital in Banff will become a smoke-free zone later this year.
The move follows a successful pilot scheme at Turriff Hospital, which introduced a tobacco ban in January.
NHS Grampian wants all its healthcare premises to be no smoking zones by the end of 2015.
Staff at Chalmers will be asked to encourage patients and visitors to consider smoking cessation and tobacco replacement items such as nicotine patches.
In-patients will be offered products which will help them stop or at least deal with cravings.
Public health co-ordinator, George Rutten, is leading the roll-out of the scheme across the area.
“People are increasingly aware that smoking is a major cause of preventable ill health and premature death,” he said. “Creating smoke free healthcare sites is one way for NHS Grampian to promote good health and wellbeing and set an example.”
The Banff, Gamrie and Deveron medical practices, which are based at the hospital site, will also be included in the ban.
A recent study showed tobacco use is associated with more 1,000 deaths in Grampian every year, as well as nearly 5,000 hospital admissions. Tobacco-related illness is estimated to cost NHS Grampian £30million-£46.6 million per annum.
Chalmers will become completely smoke-free on Monday, September 1.
Senior charge nurse Kirsty Gibb said: “We are delighted that Chalmers Hospital has been chosen as the latest location for NHS Grampian’s smoke-free site.
“We want to encourage patients, staff and visitors to the hospital to breathe fresh air wherever they are.”
Tobacco control co-ordinator, Derek Petrie, added: “NHS Grampian has a duty of care to protect both its staff and those who visit its premises from potential harm due to smoking.
“We are making key steps towards achieving successful implementation of the organisation’s tobacco policy.”