The A87 was closed for more than two hours after a two-car crash north of Portree.
The A87 closed in both directions at the A830 Borve junction after an incident which took place at around 4.25pm.
The road reopened at 7.34pm the same night, Traffic Scotland confirmed.
Traffic is now flowing as normal.
It is not yet clear if there has been any serious injuries.
Meanwhile, the fire service also confirmed they were on the scene with two appliances.
A fire service spokeswoman said they received a call at 4.55pm.
They sent two appliances to the scene from their stations in Portree and Dunvegan.
A police statement said: “The A87 is closed in both directions between Portree and Borve following a crash involving two vehicles at the A850 Junction.
“The incident was reported around 4.25pm on Wednesday, May 21.”
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