Jamie Stevenson, Paddy Boyle, Cammy Eadie, David Ferguson, Scott Hooper and Jack Leitch have all left Peterhead.
Changes in personal circumstances are behind defenders Boyle and Eadie departing the Blue Toon.
Budget cutbacks mean manager Jim McInally has been unable to make suitable offers to defenders Stevenson and Ferguson and midfielder Leitch, with full-time side Raith Rovers understood to be keen on signing the latter.
Stevenson, 36, was the club’s longest serving player having joined in the summer of 2014.
During his time at Balmoor, he helped the Buchan side reach the 2016 Challenge Cup final where they faced Rangers at Hampden and win League Two last year.
Having started out as a winger, Stevenson has transitioned to full-back in recent seasons.
McInally said: “It’s sad and we go back a long way. I know it’s football and things change and players move on but it doesn’t stop you being sentimental.
“Jamie probably should have played at a higher level during his career, but I’ve been lucky to have him and Peterhead has been lucky to have him.
“Trying to replace guys like Jamie is the really hard part of management.
“He can play a number of different positions, the last couple of seasons he’s excelled at at right-back, but he’s been great for us further forward as well.
“He’s 36 now and he’s started to pick up a few more injuries and it takes longer to recover.
“That’s maybe partly to do with the travelling he was putting in to play for us and also his job driving lorries.
“I think he feels it’s better to be closer to home to allow himself a better chance to balance work and football, but that doesn’t stop it being sad.
“I’ve got a lot of good memories with Jamie, he’s a great guy and a great professional.”
Thirty-three-year-old Boyle, another member of the 2018-19 League Two winning team, has spent two years with Peterhead and has now joined Lowland League side Kelty Hearts, alongside fellow defender Hooper.
McInally added: “Paddy’s graduated from university and he’s going to be a PE teacher so he won’t have the time to get to training and give us the time that’s required.
“Paddy has opted to leave and I did see it coming, but that doesn’t make it any easier.
“Last season especially I thought Paddy had a great season. Defensively he was really good and he’s another good guy and good professional.”
Leitch, 25, has been with Peterhead for three seasons, it was his brace against Queen’s Park at Hampden in May last year that secured the League Two title.
McInally said; “He was a massive part of that league winning team and he’s been a great player for us over the last three seasons. He’s got a brilliant attitude and he’s a brilliant professional.
“He’s a technical player, but I think during his time with us he’s added an incredible work-rate to his game. He gives you everything and that’s required at lower league level and he’s done it really well.”
Eadie, 22, has spent two years with Peterhead, while 24-year-old Ferguson joined last August.
McInally said: “Cammy will be a big loss, he’s got good pace he’s aggressive and is a good defender. I’m sure he’ll do a good turn for somebody else.
“For David, it’s just about getting that bit of consistency, but he’ll go and do well for somebody else.”
